The Industrial Phase-Transfer Catalysis Experts

PTC Tip of the Month E-Newsletter

PTC Tip of the Month - May 2017

Business Challenge for Our Readers: PTC Combined with Microreactors

By Marc Halpern, the leading expert in industrial phase-transfer catalysis.

Over the past decade, we have written several times about the potential to achieve outstanding processes by combining the strengths of liquid-liquid PTC systems for high reactivity in continuous processes with the strengths of microreactors to conduct fast reactions with excellent heat transfer and low heat history in continuous processes.

Corning is a leader in the production of microreactors made of glass or silicon carbide that can endure reaction conditions up to 18 bar and 200 C.

At Informex 2017, we were able to take these pictures of microreactors. The large unit shown contains an array of microreactors with a production capacity of up to about 2,000 tons of product per year.

commercial scale microreactor

At PTC Organics, we have always known that phase-transfer catalysis is a solution looking for a problem. Similarly, Corning knows that microreactor technology is a solution looking for a problem.

We believe that there is great opportunity to make a lot of money, even for a small company or startup, by LEVERAGING THE COMBINATION OF:

[1] the greatly reduced CHEMICAL energy of activation of phase-transfer catalysis in liquid-liquid PTC systems in 30 broad reaction categories with

[2] the greatly enhanced heat transfer, controlled agitation and other PHYSICAL characteristics provided by microreactors.

The potential to make money is limited only by the creativity of our readers to identify “problems” in search of the solution that is the combination of PTC with microreactors. This challenge requires knowledge of chemical market opportunities, highly specialized PTC expertise and engineering expertise in microreactors.

Please contact Marc Halpern of PTC Organics if you are aware of a chemical challenge, especially one that requires high selectivity or high productivity or short heat history and is a strong base reaction, nucleophilic substitution, oxidation or reduction. We will be happy to sign a CDA and explore development and commercialization.

Closeup picture of several microreactors:

Informex 2017 micro-reactors Corning

 

About Marc Halpern

Marc Halpern

Dr. Halpern is founder and president of PTC Organics, Inc., the only company dedicated exclusively to developing low-cost high-performance green chemistry processes for the manufacture of organic chemicals using Phase Transfer Catalysis. Dr. Halpern has innovated PTC breakthroughs for pharmaceuticals, agrochemicals, petrochemicals, monomers, polymers, flavors & fragrances, dyes & pigments and solvents. Dr. Halpern has provided PTC services on-site at more than 260 industrial process R&D departments in 37 countries and has helped chemical companies save > $200 million. Dr. Halpern co-authored five books including the best-selling “Phase-Transfer Catalysis: Fundamentals, Applications and Industrial Perspectives” and has presented the 2-day course “Practical Phase-Transfer Catalysis” at 50 locations in the US, Europe and Asia.

Dr. Halpern founded the journal “Industrial Phase-Transfer Catalysis” and “The PTC Tip of the Month” enjoyed by 2,100 qualified subscribers, now beyond 130 issues. In 2014, Dr. Halpern is celebrating his 30th year in the chemical industry, including serving as a process chemist at Dow Chemical, a supervisor of process chemistry at ICI, Director of R&D at Sybron Chemicals and founder and president of PTC Organics Inc. (15 years) and PTC Communications Inc. (20 years). Dr. Halpern also co-founded PTC Interface Inc. in 1989 and PTC Value Recovery Inc. in 1999. His academic breakthroughs include the PTC pKa Guidelines, the q-value for quat accessibility and he has achieved industrial PTC breakthroughs for a dozen strong base reactions as well as esterifications, transesterifications, epoxidations and chloromethylations plus contributed to more than 100 other industrial PTC process development projects.

Dr. Halpern has dedicated his adult life to his family and to phase-transfer catalysis (in that order!).

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