Last week at Informex, I had the pleasure of meeting with Steel Hutchinson, the president of GFS Chemical. We discussed lithium perchlorate and magnesium perchlorate and the stigma perchlorates have that prevents chemists from screening them for a variety of organic chemical reactions.
It turns out that LiClO4 can be used for Diels-Alder, Glycosylations, Friedel-Crafts acylations, transesterifications and other reactions. You can get a 44-page monograph with more than 200 references about perchlorate reactions by contacting GFS and asking for “GFS publication #495 – Practical Use of Anhydrous LiClO4 and Mg(ClO4)2 in Organic Synthesis”
Some of the publications use ether as solvent. One could speculate whether polyethylene glycols (e.g., PEG-400) could serve as complexing phase-transfer catalysts to transfer Li perchlorate into organic solvents and activate the “naked” ions to perform the reactions at shorter reaction times than those shown in the monograph. Of course, one would need to perform hazard operations analysis before running any such reactions and GFS has expressed commitment to provide technical and safety data for perchlorates.
If your company can benefit from achieving higher process performance in a shorter development time by having access to the best PTC expertise available, now contact Marc Halpern by E-mail to inquire about using phase-transfer catalysis to achieve low-cost high-performance green chemistry.
If you’re not sure if PTC can help your reaction, now fill out the form shown at http://phasetransfer.com/projectform.pdf and send it to Marc Halpern by fax at +1 856-222-1124 or by E-mail of a scanned copy. If we do not have a secrecy agreement already in place, please use “R-groups” instead of the exact chemical structures.