Module 1 – Day 1
Learn How to Choose PTC Process Conditions Like an Expert
8:30 Introduction
Phase-Transfer Catalysis Overview
PTC Mechanism
“I-Reaction” and “T-Reaction”
The PTC Rate Matrix
Introduction to Understanding Interactions Between Catalyst, Hydration, Solvent and Anions
10:15 Break
10:30 Choosing Process Parameters
Choosing Catalyst
Structure Activity Relationships
including systematic approach for predicting and selecting catalyst for reactivity
effective catalyst separation methods
including minimizing residue and waste
catalyst recycle
catalyst stability
toxicity
availability
12:00 Lunch
1:15 Choosing Process Parameters – continued
Anions, Leaving Group and Catalyst Poisoning
Hydration (dramatic effects and control)
Practical Aspects of Solvent
Solvent-Free PTC
Agitation
“Third Phase” PTC (not triphase PTC)
2:45 Break
3:00 Practical Guidelines
Guidelines for Identifying, Evaluating and Optimizing New PTC Applications
A 3-5 Experiment Program for Screening & Resource-Efficient R&D
Patentable Opportunities
Identifying Opportunities
The 60-Second PTC Test
4:00 PTC Exercises
5:00 Conclusion – Module 1
Module 2 – Day 2
PTC Applications
8:30 Applications – Strong Base Reactions
C-Alkylation
Chiral Alkylation
O-Alkylation
S-Alkylation
N-Alkylation
10:15 Break
10:30 Applications – Strong Base Reactions – continued
Michael Addition
Aldol Condensation
Wittig, Darzens
Other Condensations
Dehydrohalogenation
Carbene Reactions
Applications – Nucleophilic Substitutions
Esterification
Transesterification
O-Acylation & Thiophosphorylation
Use of Water-Sensitive Reactants in PTC Substitutions
12:00 Lunch
1:15 Applications – Nucleophilic Substitutions – continued
Cyanide
Azide
Fluoride
Other nucleophilic aliphatic and aromatic substitutions
Applications – Oxidation
Oxidations
Hydrogen Peroxide
Hypochlorite
Other oxidizing agents
Epoxidations
2:30 Break
2:45 Applications – Reduction & Other
Reductions
Borohydride
Hydrogenation
Other reducing agents
Transition Metal Co-Catalysis
Additional PTC reactions and exercises
4:00 PTC Exercises
5:00 Conclusion – Module 2
Links:
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