The Industrial Phase-Transfer Catalysis Experts

PTC Tip of the Month E-Newsletter

PTC Course Agenda


Module 1 – Day 1

Learn How to Choose PTC Process Conditions Like an Expert

 

8:30 Introduction

Phase-Transfer Catalysis Overview

PTC Mechanism

“I-Reaction” and “T-Reaction”

The PTC Rate Matrix

Introduction to Understanding Interactions Between Catalyst, Hydration, Solvent and Anions

 

10:15 Break

 

10:30 Choosing Process Parameters

Choosing Catalyst

Structure Activity Relationships

including systematic approach for predicting and selecting catalyst for reactivity

effective catalyst separation methods

including minimizing residue and waste

catalyst recycle

catalyst stability

toxicity

availability

 

12:00 Lunch

 

1:15 Choosing Process Parameters – continued

Anions, Leaving Group and Catalyst Poisoning

Hydration (dramatic effects and control)

Practical Aspects of Solvent

Solvent-Free PTC

Agitation

“Third Phase” PTC (not triphase PTC)

 

2:45 Break

 

3:00 Practical Guidelines

Guidelines for Identifying, Evaluating and Optimizing New PTC Applications

A 3-5 Experiment Program for Screening & Resource-Efficient R&D

Patentable Opportunities

Identifying Opportunities

The 60-Second PTC Test

 

4:00  PTC Exercises

5:00  Conclusion – Module 1

 

 

Module 2 – Day 2

PTC Applications

 

8:30 ApplicationsStrong Base Reactions

 C-Alkylation

Chiral Alkylation

O-Alkylation

S-Alkylation

N-Alkylation

 

10:15 Break

 

10:30 ApplicationsStrong Base Reactions – continued

 Michael Addition

Aldol Condensation

Wittig, Darzens

Other Condensations

Dehydrohalogenation

Carbene Reactions

 

ApplicationsNucleophilic Substitutions

Esterification

Transesterification

O-Acylation & Thiophosphorylation

Use of Water-Sensitive Reactants in PTC Substitutions

 

12:00 Lunch

 

1:15 ApplicationsNucleophilic Substitutions – continued

 

Cyanide

Azide

Fluoride

Other nucleophilic aliphatic and aromatic substitutions

 

ApplicationsOxidation

 Oxidations

Hydrogen Peroxide

Hypochlorite

Other oxidizing agents

Epoxidations

 

2:30 Break

 

2:45 ApplicationsReduction & Other

 Reductions

Borohydride

Hydrogenation

Other reducing agents

Transition Metal Co-Catalysis

Additional PTC reactions and exercises

 

4:00 PTC Exercises

 

5:00 Conclusion – Module 2

 

Links:

Click here to register for PTC Course In Philadelphia Oct 21-22, 2014

Click here for in-house PTC Course